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Researchers from Copenhagen concurred last year in a review of GLP-1 drugs, saying that theres limited information on their long-term safety, particularly concerning pregnancy outcomes. Reasons for concern come mostly from animal experiments

Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C et al (2011) Catalytic activity of the caspase-8FLIPL complex inhibits RIPK3-dependent necrosis

Ready-to-use formulations and easy-to-use delivery systems such as single-dose prefilled pens and hidden, pre-attached needles may encourage patient acceptance (58)