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As valproic acid levels begin to fall below a therapeutic level, either: (1) An alternative and safer anti-epileptic agent may be added

Consequently, Heart-failure research reported improved ejection fraction, fibrosis, mitochondrial function, and survival in a pressure-overload mouse model using SLU-PP-332 and SLU-PP-915

Similarly, in a model of neurotoxicity, excess GPx-1, as well as antioxidants, such as MitoQ, attenuated cellular ROS, thereby leading to a decrease in activation of the caspase cascade and a reduction in apoptotic cell death (191)

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Integration of a multitude of omics data such as genomics, microbiomics, and metabolomics, with individual clinical and preclinical profiling, will help in the development of tailored management strategies for individuals susceptible to microbiome-associated depression