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Based on Phase 2 studies, the initial dose may begin at 1 mg to 2 mg (0.0750.15 mL) once weekly, with gradual titration every 4 weeks in increments of 2 mg to 4 mg, as tolerated, up to a maximum of 12 mg (0.90 mL) weekly Doses between 4 mg and 12 mg weekly demonstrated meaningful reductions in body weight and glycemic parameters over 16 to 28 weeks

Increase water intake, add fiber gradually (not all at once), and consider magnesium citrate as a gentle osmotic support

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Weekly subcutaneous injections deliver steady hormone levels, avoiding the concentration spikes that trigger side effects with daily dosing