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Semaglutide's weight-management evidence sits mainly in the STEP program, published in The New England Journal of Medicine in 2021

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Notably, the oncogenic drivers prevalent in PDAC, such as mutant KRAS and loss of TP53 or SMAD4, intricately modulate key ferroptotic pathways, including the System Xc/GSH/GPX4 axis, the FSP1-CoQH system, and lipid metabolism networks, thereby dictating cellular susceptibility to ferroptotic stress

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