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56, 2012, pp

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Oxidative stress does not occur randomly it is driven upward by: undermethylation copper overload immune activation high sugar diets nutrient deficiencies sleep disruption physical or emotional stress environmental exposures When antioxidants are low, the brain cannot: regulate sensory input maintain mitochondrial energy detoxify inflammatory byproducts stabilize mood or attention manage stress hormones This creates a vulnerability window a period in which developmental timing can be disrupted by ordinary childhood stressors

Furthermore, as a hallmark of the aging population, m -Dys could onset chronic inflammation with massive cytokine release and cause multi-organ failure with fatal outcomes in elderly COVID-19 patients 177

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