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This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes

9 Rather than functioning as a stand-alone approach, glutathione is more commonly considered as one variable within complex mood and inflammatory profiles, especially when oxidative stress or low-grade inflammation appears to contribute to the overall clinical picture