Some may need to accept less total weight loss in exchange for preserving functional capacity and independence
3.2.2 HbA1c changes Evaluating the impact of Semaglutide compared to Dulaglutide on HbA1c alteration, our analysis uncovered a notable advantage of Semaglutide in reducing HbA1c levels when compared with Dulaglutide
Bennet L, Groop L, Lindblad U, Agardh CD, Franks PW
These cellular changes, while not immediately noticeable, contribute to the long-term success and health benefits associated with semaglutide treatment
The key mechanisms include: Appetite suppression: Semaglutide acts on hypothalamic centers in the brain to reduce hunger and increase satiety Delayed gastric emptying: Food moves through the stomach more slowly, prolonging the feeling of fullness Improved insulin sensitivity: Better glucose regulation reduces insulin-driven fat storage Reduced food reward signaling: Semaglutide appears to decrease the neurological reward response to food In the STEP 1 clinical trial, participants receiving semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks compared to 2.4% with placebo (Wilding et al., 2021, New England Journal of Medicine )
