glutathione composed of cysteine glycine glutamate metabolic pathways. GCL, ligase; GST, Glutathione Biochemistry | Glutathione Synthesis

Nat Rev Mol Cell Biol (2022) 23:581

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(2021) Application of biosensors based on nanomaterials in cancer cell detection

In this case, the interaction of the reduced glutathione with the sulfene group first leads to the appearance of a mixed disulfide formed by the protein and glutathione: Pt-SOH + GSH PtS-SG + 2 and then to the reduction of the thiol group of the protein PtS-SG + GSH Pt-SH + GSSG The importance of the reduction reaction of thiol groups of proteins with glutathione is explained by the fact that the formation of sulfene ionic groups in the molecules of a number of proteins that regulate the phenotypic properties of cells changes the properties of these proteins

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