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stimulates pulsatile GH release without raising cortisol or prolactin Key safety concern / Unknown effects on a still-maturing hypothalamic-pituitary-gonadal axis Guideline position / No endorsement from Endocrine Society, AAP, or AACE for pediatric use Compounding status / Available only through 503A/503B compounders

Metformin might help aid weight loss, as it helps stabilise blood sugar levels so there are less glucose fluctuations which is what increases hunger or even leads to overeating

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doi: 10.1042/BJ20020752