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The systemic neural inflammatory connection is evident in the higher levels of biomarkers such as CRP, IL-6, and TNF- in COPD

Characterized by excessive fat accumulation in the liver, NAFLD can progress to more severe conditions, including nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even liver cancer

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Two decades later Joseph von Mering and Oscar Minkowski, two German physicians based at the University of Strasbourg, showed in a dog that the surgical removal of the pancreas, known as a pancreatomy, immediately caused severe and fatal diabetes