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Some people experience it only during the first few weeks, while others may deal with mild discomfort for longer

An elevated or rising ratio during therapy indicates inflammation or tissue stress, a signal that cellular health is under strain

This is a landmark finding, says Bert Mandelbaum, M.D., a sports medicine specialist and orthopedic surgeon at Cedars-Sinai Kerlan-Jobe Institute and Co-Director of the Regenerative Orthobiologic Center at Cedars-Sinai Medical Center in Los Angeles

In the diabetes trial, the primary endpoint was a change in glycated hemoglobin (HbA1c) values from baseline to week 24

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