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As weight loss with any existing pharmaceutical intervention inevitably plateaus due to putative counterregulatory mechanisms, we further hypothesized that the postulated enhanced body weight suppressive effects of combined amylin- and GLP-1R-based pharmacotherapies could be even further enhanced if the drugs were introduced in a stepwise fashion, allowing the physiological systems to adjust to and overcome the tachyphylaxis that occurs with repeated drug treatments 21,22,23

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Alzheimers Dement (2021) 17:196675

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NICE guidance supports bariatric surgery for adults with a BMI of 40 kg/m or greater, or 35 kg/m or greater with significant comorbidities (with lower thresholds for certain ethnic groups), following multidisciplinary team assessment