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Beyond the GI profile, the NEJM Phase 2 trial also logged back pain as a low-rate adverse event across dose groups, and a small number of pancreatitis and gallbladder events were recorded at higher doses the full NEJM 2023 retatrutide obesity trial adverse events line-listing (abdominal pain, back pain, pancreatitis, gallbladder) is why many researchers pair the stomach pain discussion with back pain when reviewing the data

The commercial answer and the cultural answer are different

Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help right away in the event of a known or suspected overdose (see WARNINGS, Life-Threatening Respiratory Depression)

Consult a healthcare professional if you experience intense pain, expanding redness, swelling, or symptoms of infection such as pus or fever

Another way to perform Kegel exercises is to interrupt the flow of urine for several seconds while urinating