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The crude material was purified by automated flash column chromatography on silica via gradient elution, from 100% dichloromethane to 1% methanol in dichloromethane to produce SS(NHS-CM) 2 (979 mg, 79%) as an off-white foamy solid

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Recently, it was also found that activation of ferroptosis by erastin increases the level of lysosomal-associated membrane protein 2a, thereby promoting chaperone-mediated autophagy, which in turn promotes the degradation of GPX4 7

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L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle