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This pattern suggests that with repeated dosing, nonspecific behavioral effects such as malaise or sedation may diminish, potentially reflecting pharmacodynamic adaptation or increased tolerability

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Some research suggests these medications may cause mild vasodilation and potentially reduce systemic vascular resistance, which could trigger a compensatory increase in heart rate to maintain cardiac output and blood pressure

doi: 10.1371/journal.pone.0198024 [DOI] [PMC free article] [PubMed] [Google Scholar] 27

We might start peptide therapy