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Malignant causes require consideration, particularly in patients with persistent or progressive lymphadenopathy
The Gap Between an Association and an Indication Observational database studies are useful for generating hypotheses and for detecting signals across populations too large to randomise
Over-the-counter remedies like simethicone (Gas-X) or digestive enzymes may provide short-term relief, though they work differently and don't address the root cause
Nature Reviews Drug Discovery, 6(10), 821833.
However: No large, peer-reviewed human trials exist demonstrating proven benefit
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