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Future research should integrate genomics, metabolomics, and microbiomics to develop biomarker-based personalized dietary intervention protocols, thereby enhancing therapeutic efficacy while reducing potential risks (Table 1)

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Dyslipidaemia (odds ratio (OR) 1.6), hypertension (OR 1.5), and concurrent biologic therapy (OR 1.5) were all associated with increased likelihood of GLP-1 agonist use, highlighting the interconnected nature of metabolic and inflammatory conditions in HS management