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doi: 10.1056/nejmc1602096

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Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J, American Heart Association Statistics C and Stroke Statistics S (2011) Heart disease and stroke statistics2011 update: a report from the American Heart Association

Deiodination of thyroid hormones The figure illustrates the deiodination of thyroidT hormones, catalyzed by selenium-dependent enzymes called iodothyronine deiodinases (DIOs)

Clinically Relevant Experimental Animal Models Because of the limitations/difficulties related to human studies due to in part to ethical concerns, the use of experimental animal models becomes an important alternative to investigate disease pathogenesis