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In recent years there has been accumulating evidence that microbes are involved in AD pathogenesis that has been covered in a large number of reviews, many of which call for investigation of antimicrobial therapies (Vigasova et al., 2021

They reported 5-hydroxymethylfurfural (5-HMF) levels of 1.88, 4.32, 4.82, and 4.08 g/kg, respectively, indicating that lower temperatures over extended durations result in lower HMF formation

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