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The primary effectors of cAMP, protein kinase A (PKA), and the cAMP-regulated guanine nucleotide exchange factor (Epac) play crucial roles in this process [22]

Semaglutide has a longer track record of clinical use, while tirzepatide is newer and may be considered for specific patient needs, including those who plateau on semaglutidesubject to clinician judgment and eligibility

GLP-1 shares a highly conserved alanine at position 9 with GIP and GLP-2, making these peptides ideal substrates for dipeptidyl peptidase 4 (DPP-4)

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3-Nitrophenyl hydrazine based quantification of kynurenine and tryptophan The sample preparation 3-Nitrophenyl hydrazine (NPH) derivatization method was carried out as described in [56, 57]