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For instance, it remains undefined whether PKD1/PKD2 loss-of-function directly modulates the transcription or stability of ferroptosis regulators (e.g., SLC7A11, GPX4, and TFR1) or indirectly via downstream signaling cascades (e.g., cAMP/PKA and mTOR, which are known to be dysregulated in ADPKD)

Tirzepatide combines the incretin effects of GLP-1 with GIP, the latter of which contributes to appetite regulation and further reductions in food intake

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