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One observed a reduction in lower limb pain scores within 3 months at most locations, while some locations such as the lower medial third of the leg and medial upper third of the thigh were less affected

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All 12 reported significant symptom improvement with no reported adverse effects

This can go up depending on the previously discussed factors above

174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)