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hirae encode essentially the same Cu I -specific P 1B-1 -type ATPase efflux transporter (Section 5.3) whose Cu I -inducible transcription is regulated by three structurally distinct Cu I -sensing metallosensors, CsoR, 203 CueR (a MerR family member), 249 and CopY, 200 respectively

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The cardiovascular and respiratory side effects include chest pain, tachycardia (increased heart rate), heart palpitations, low blood pressure, and chest tightness, cough with or without production of pink frothy sputum, wheezing and difficulty breathing