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doi: 10.1016/j.jscs.2010.06.006 135 ZhangZ.NieD.FanK.YangJ.GuoW.MengJ.et al (2020)

By summarizing the effects of selenium and selenoproteins on a variety of different diseases, it is not difficult to conclude that selenium supplementation may play a dual role as it exerts anti-inflammatory and antioxidant effects at nutritional doses but reverses these effects at supernutritional doses

Consistent with a moderate increase of these well-described changes in healthy aging, we observed significantly higher levels of malondialdehyde (MDA), a marker for circulating levels of lipid peroxides, in older adults compared to the levels of young subjects (means, young = 0.136, older adults = 0.158 mol/L, p -value 300 uM in older adults is within the range of what has been described as being associated with elevated cardiovascular risk compared to that of young subjects (El-Khairy et al., 2001)