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This is because these neurons have high levels of mitochondrial activity, which leads to the generation of reactive oxygen species (ROS) as a by-product
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When the transport of dopamine into synaptic vesicles is obstructed or VMAT2 is inhibited by drugs such as tetrabenazine and reserpine, excessive dopamine can accumulate in the cytoplasm, leading to the auto-oxidation of dopamine and the formation of harmful by-products, eventually leading to neurodegeneration
[DOI] [PubMed] [Google Scholar] 92.Rezaei M., Javadmoosavi S.Y., Mansouri B., Azadi N.A., Mehrpour O., Nakhaee S
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