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In a minority of patients, MS begins with a progressive course from onset where inflammation may be less prominent, though still plays a role in disability progression (Hughes et al., 2018)

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The PI3K/AKT/mTOR pathway was recently showed to reduce oxidative stress and promote cell survival of breast epithelial cells segregated from the ECM by strengthening flux through the oxidative PPP (195) PIK3CA mutation, which leads to increased PI3K activity, is the most common somatic mutation in breast cancer, and 36% of patients with HR+/HER2- breast cancer are PIK3CA mutated (196)

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Obesity is characterized by chronic low-grade systemic inflammation, with elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and C-reactive protein