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This work was funded by ShanghaiTech University, the National Program on Key Basic Research Project of China (2018YFA0507004 to W.S.), National Natural Science Foundation of China (31971362, 32171439 to W.S.) and Shanghai Natural Science Foundation Grant (18ZR1425100 to X.H.)

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The study used databases at the Toronto-based Institute for Clinical Evaluative Sciences to review the patient records of 146,850 residents of the province aged 65 or over who were prescribed regular vitamin B12 shot between January 2011 and October 2015

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