soul trial oral semaglutide cardiovascular outcomes results 2025 nejm In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide. https://ja.ma/3JO2SQc Oral Semaglutide and Cardiovascular Outcomes

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The citrate in excess of mitochondrial requirements is exported in the cytosol, converted into acetyl-CoA by ATP-citrate lyase (ACLY), and used for protein acetylation and lipogenesis

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This multi-pathway approach is what sets retatrutide apart from more familiar medications that focus on only one hormone system

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