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Muscle preservation: Because AOD 9604 targets adipose tissue specifically and does not suppress systemic anabolic signaling, researchers have hypothesized that it may allow for fat loss with less collateral impact on lean mass, though this has not been formally tested in head-to-head trials

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There is a boxed warning regarding thyroid C-cell tumors based on rodent studies, with a contraindication in patients with personal or family history of MTC or MEN2

Oral supplementation of N acetylcysteine (NAC) and Se after TBI can alleviate oxidative stress by inhibiting ROS production and increasing the expression level of GPX, and at the same time downregulate the level of proinflammatory (IL1) cytokines and upregulate the level of antiinflammatory (IL4) cytokines to alleviate inflammatory stimulation, thereby showing a neuroprotective effect on TBI [184]