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Applying REWIND cardiovascular disease criteria to SUSTAIN 6 and LEADER (comparative analysis of GLP-1 cardiovascular outcome trials)

The efficacy difference is substantial

Research shows curcumin stimulates GLP-1 secretion in the intestinal L-cells where natural GLP-1 is produced- in a dose-dependent manner

14 The Liver: After passing through the gut wall and entering the portal circulation, the drug is delivered to the liver, which is the body's primary metabolic organ

Among these, miR-133b has been associated with lipid-rich plaques independent of traditional cardiovascular risk factors, suggesting its potential as a biomarker of plaque vulnerability (Table 1, they may not fully capture localized plaque biology