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When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s

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Transcriptional coactivator with the PDZ-binding motif (TAZ) is crucial in Th17 differentiation [42]

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