The FLOW trial, the first dedicated kidney outcomes trial designed specifically to evaluate a GLP-1 medicine in people with chronic kidney disease and type 2 diabetes, was stopped early because an independent monitoring committee determined that clear evidence of benefit had already emerged.[11] In clinical research, trials are rarely stopped early
The Lancet and Nature Communications data suggest this is a real pharmacological effect rather than a reporting artifact
Tolerability, safety and pharmacodynamics of oral, small-molecule glucagon-like peptide-1 receptor agonist danuglipron for type 2 diabetes: a 12-week, randomized, placebo-controlled, phase 2 study comparing different dose-escalation schemes
GLP-1 medications require continuous use to maintain therapeutic results
However, make sure you still aim to rotate injection sites regularly