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Furthermore, Annexin V-FITC/PI double staining illustrated the mechanism of the cytotoxic properties of BV in T-47D and resistant cells through apoptosis, which was confirmed with increased expression of pro-apoptotic protein (BAX) and reduced levels of the anti-apoptotic (Bcl-2) protein, as shown immunohistochemically in vivo

Elevated levels of oxidative stress as a result of G6PD deficiency cultivate a favorable environment for viral replication, consequently deteriorating the course of infection [12]

Infection, some medications and foods with high level of convicine, vicine, divicine and isouramil such as fava beans can cause oxidative stress

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doi: 10.2174/092986706777452542 91 FraternaleA.ZaraC.De AngelisM.NencioniL.PalamaraA