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HRS-4729 (Jiangsu Hengrui / Kailera Therapeutics) - injectable peptide, Phase 1 initiated January 2025

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Tirzepatide (but not semaglutide) has been shown to have the following effects on oral contraception, which were not seen for semaglutide, or any of the less commonly used GLP-1 agonists

Metabolic and vascular risk factors are associated with reduced cerebral blood flow and poorer midlife memory performance