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[DOI] [PMC free article] [PubMed] [Google Scholar] Huang Y, Coupland NJ, Lebel RM, Carter R, Seres P, Wilman AH, Malykhin NV

Among them, drugs need to overcome the first pass effect of the liver and the blood-ocular barrier to reach the eye, so their bioavailability is relatively low

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Theres also plenty of buzz about retatrutide, which is in a different class