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It has been used to control blood sugar in certain people with type 2 diabetes, assist weight loss in some patients, and now treat obstructive sleep apnea in adults with obesity

However, the symptom duration is similar between the two medications (46 weeks at stable dose), and tirzepatides higher efficacy for weight loss (20.9% vs 14.9% mean reduction) offsets the modestly higher GI burden for most patients

Off-Label and Investigational Uses of Tirzepatide Mounjaro Weight loss Tirzepatide has demonstrated significant weight reduction in non-diabetic individuals with obesity

Clinical trials for pharmaceutical-grade oral tirzepatide are ongoing

The majority of patients who discontinued ZEPBOUND due to adverse reactions did so during the first few months of treatment due to gastrointestinal adverse reactions