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The current and emerging anti-obesity treatments constitute long-lasting analogs of intestinal epithelial cellexpressed incretins that signal through their cognate G proteincoupled glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-induced insulinotropic polypeptide (GIP) receptor (GIPR)

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ESSENCE data suggest that Wegovys impact on histologic endpointsresolution of steatohepatitis without fibrosis worsening and 1stage fibrosis improvement without MASH worseningmay be mediated through these pathways and possibly direct GLP1 receptorrelated effects, although the exact mechanistic contribution beyond weight loss remains an area of active research

doi: 10.1210/jcem.75.2.1379256 82 U.S