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Introduction: GABAergic system as a substrate for brain plasticity During the last decades neuroscientists and physiologists worldwide have made an herculean effort to elucidate the mechanisms of activity-driven changes in synaptic strength and understand its physiological significance as the brain substrate for learning and memory (Malenka and Bear, 2004

This means plasma concentrations fall by half every 6 days, enabling once-weekly subcutaneous dosing

Many patients report less tiredness within two to four weeks of starting injections, depending on how depleted their levels were at baseline

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