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GLP-1 medications can cause nausea, vomiting, and gastrointestinal discomfort particularly when doses are escalated too quickly

Snyder PJ, Bhasin S, Cunningham GR, et al

[6] Whether these combined effects meaningfully contribute to changes in skin physiology such as altered sensitivity or localised reactions remains speculative and has not been confirmed in published clinical trial data

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GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1-induced metabolic disturbance and mitochondrial dysfunction