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Zhou G, Myers R, Li Y, et al

Inflammasomes promote the maturation and secretion of the cytokine precursors pro-IL-1 and pro-IL-18 in the process of innate immune defense by inducing the activation of caspase-1, thereby triggering an inflammatory response

DNA sequence changes are not found in these epimutations and they are thought to be random stochastic errors occurring in spermatogenesis of the fathers