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The substantial comorbidity burdenapproximately 30% of inflammatory bowel disease patients develop anxiety or depressionhighlights the urgent need for dual-effect therapies that simultaneously address intestinal inflammation and gut-brain axis modulation

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Resources We Trust Cleveland Clinic: Ozempic Babies: How GLP-1 Agonists Affect Fertility Mayo Clinic: New Study Links Combination of Hormone Therapy and Tirzepatide to Greater Weight Loss After Menopause

Ligand-activated PPAR can inhibit NF-B signaling by impeding p65 nuclear translocation and reducing p65/PPAR complex formation (81)

Diagnostic tests showed no significant deviations from normality or heteroskedasticity in these models