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A study by our group [80] showed that when erythrocytes were saturated with CO, the enzyme Prx2 was present in the cytosol only in the monomeric form, suggesting that Prx2 was not acting as a peroxidase but, instead, exclusively as a chaperone for Hbs protection

While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)

These symptoms included progressive memory problems coupled with psychiatric disturbances

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(2017) Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine, EMBO J