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The age-related decline in neuromodulator levels, combined with the lack of significant learning and memory effects from PXN LOW in aged animals (though a trend was noted, P = 0.07), may explain the reduced cognitive benefits of both caffeine and paraxanthine in older individuals

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However, as we age or face certain health challenges, our glutathione levels can deplete, leading to increased oxidative stress and potential health concerns

doi: 10.3390/jcm8111992 67 ViriliCTrimboliPCentanniM

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