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Background Type 2 diabetes mellitus (T2DM) is a chronic condition that affects millions of patients worldwide, posing significant challenges to both patients and healthcare systems

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A major milestone came in December 2025, when the FDA approved oral Wegovy (semaglutide 25 mg tablet) as the first oral GLP-1 for weight loss, showing 16.6% mean weight reduction in the OASIS 4 trial ( [8] )

These mice show markedly increased plasma insulin concentrations in the fed state due to enhanced activity of the enteroinsular axis [27]