Herrera-Abreu, M
Key findings (Vafaei et al., 2025): 30-50 mg/kg mirtazapine: dose-dependent seizure suppression Mediated by CB1/CB2 activation (proven by antagonist blockade) GABA-independent mechanism (distinct from benzodiazepines) Appetite/weight gain provides in-vivo functional validation of CB1 engagement The broader implication: Clinicians and researchers have been using ECS pharmacologyunknowinglyfor decades
Patient comes in and says, look, I saw X, Y, and Z celebrity, certain tennis player or somebody else, certain TV hosts, I wont mention any names, but I saw somebody and they lost all this weight
The progressive load design was deliberately chosen to push participants to their maximal effort, ensuring that the effects of supplementation on endurance performance could be fully assessed under intense conditions
There is usually a widespread morbilliform rash, high fever, lymphadenopathy, haematological abnormalities, and internal organ involvement, such as hepatitis