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T2DM is characterized by pancreatic -cell dysfunction and insulin resistance, and is recognized as a multisystem metabolic disorder involving pathways such as the gut-brain axis, insulin/peripheral resistance, etc strongly correlated with obesity and cardiovascular diseases

Sandoval declares an association with the following company: Ethicon (research support)

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Individuals carrying certain genetic variants associated with higher baseline metabolic dysfunction or altered blood pressure regulation may show different GLP-1 response profiles compared to other patients