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(1997) Role of pharmacokinetics and metabolism in drug discovery and development

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Sep 30 2022;12(10)doi:10.3390/diagnostics12102374

P450-Glo CYP3A4 activity assay CYP3A4 activity was measured using the P450-Glo CYP3A4 assay kit (Promega, catalog: V9001)

and reported that in CD patients in sustained steroid-free remission undergoing combination therapy with infliximab and an immunomodulating drug, the withdrawal of infliximab should only be considered after a careful assessment of the risks and benefits for the individual patient, whereas the withdrawal of the immunomodulatory drug could generally represent the preferred strategy [93]