This is sometimes referred to as Ozempic face. While this experience is not dangerous, it can feel surprising if weight loss happens faster than expected
In these systems, drugs are encapsulated or conjugated to nanoparticles that can penetrate biological barriers, thereby facilitating direct delivery to specific tissues or cells
In the meantime, mitochondrial dysfunction is induced by hepatic IR and lipid accumulation and the lipid peroxidation mediated by cytochrome p450 2E1 boost the production of reactive oxygen and promote the degradation of mitochondria (125), which could further lead to the lack of cellular energy and metabolic intermediates accumulation, all these may lead to the secretion of pro-inflammatory cytokines, hepatocellular apoptosis and hepatic fibrogenesis, finally resulting in cirrhosis of the liver (125) ( Figure 3 )
These studies suggest that despite the potential benefits of Lira, current evidence does not advocate the use of Lira in patients with NAFLD
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