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Phase Maintenance Weeks 25+ Tirzepatide 15.0 mg/week Cagrilintide 2.4 mg/week Notes Full 3-receptor coverage if tolerated

While we appreciate the recommendations for changing measures or re-specifying to use alternative PRO-PMs such as PROMIS Physical Function or PROMIS Pain Interference, we will adhere to the existing MIPS specifications to ensure alignment with MIPS, thereby reducing burden caused by model-specific measures and specifications

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Use the resulting supernatant as crude extract (CE) and assay it for the glutathione content

Currently available histological data indicate a dramatic restoration of tyrosine hydroxylase (TH) staining in the substantia nigra (SN) following six weeks of ip Dihexa treatment, and three months of Dihexa treatment results in nearly 100% recovery of SN TH staining(see Figure 32 of Example 4)