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Five randomized controlled trials and a single open-arm clinical study on oral glutathione at doses of 250 mg once a day, 250 mg twice a day, and 500 mg once a day showed a significant reduction in the melanin index compared to placebo

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e.g., female rats are more sensitive than males to the anorexigenic effect of a centrally administered GLP1 receptor agonist

Therefore, the skin is a notable part of the immune system and consists of numerous molecular mechanisms that protect the skin from UV radiation (28)